Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

BACKGROUND: Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. This study investigated the expressions of TS and its gene SNPs in non-small c...

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Autori principali: Wang, Xia, Wang, Yadi, Wang, Yue, Cheng, Jian, Wang, Yanyun, Ha, Minwen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577430/
https://ncbi.nlm.nih.gov/pubmed/23350714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-20-5
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