The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients

In NSCLC, second-line chemotherapy using pemetrexed or docetaxel has limited efficacy and should be dedicated to selected groups of patients. Pemetrexed is an antifolate compound with the ability to inhibit enzymes (TS, DHFR and GARFT) involved in pyrimidine and purine synthesis. The objective of th...

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Enregistré dans:
Détails bibliographiques
Publié dans:Pathol Oncol Res
Auteurs principaux: Kucharczyk, Tomasz, Krawczyk, Paweł, Powrózek, Tomasz, Kowalski, Dariusz M., Ramlau, Rodryg, Kalinka-Warzocha, Ewa, Knetki-Wróblewska, Magdalena, Winiarczyk, Kinga, Krzakowski, Maciej, Milanowski, Janusz
Format: Artigo
Langue:Inglês
Publié: Springer Netherlands 2015
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681747/
https://ncbi.nlm.nih.gov/pubmed/26277606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12253-015-9966-z
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