The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients

In NSCLC, second-line chemotherapy using pemetrexed or docetaxel has limited efficacy and should be dedicated to selected groups of patients. Pemetrexed is an antifolate compound with the ability to inhibit enzymes (TS, DHFR and GARFT) involved in pyrimidine and purine synthesis. The objective of th...

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Detaylı Bibliyografya
Yayımlandı:Pathol Oncol Res
Asıl Yazarlar: Kucharczyk, Tomasz, Krawczyk, Paweł, Powrózek, Tomasz, Kowalski, Dariusz M., Ramlau, Rodryg, Kalinka-Warzocha, Ewa, Knetki-Wróblewska, Magdalena, Winiarczyk, Kinga, Krzakowski, Maciej, Milanowski, Janusz
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Netherlands 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681747/
https://ncbi.nlm.nih.gov/pubmed/26277606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12253-015-9966-z
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