The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients

In NSCLC, second-line chemotherapy using pemetrexed or docetaxel has limited efficacy and should be dedicated to selected groups of patients. Pemetrexed is an antifolate compound with the ability to inhibit enzymes (TS, DHFR and GARFT) involved in pyrimidine and purine synthesis. The objective of th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Pathol Oncol Res
Egile Nagusiak: Kucharczyk, Tomasz, Krawczyk, Paweł, Powrózek, Tomasz, Kowalski, Dariusz M., Ramlau, Rodryg, Kalinka-Warzocha, Ewa, Knetki-Wróblewska, Magdalena, Winiarczyk, Kinga, Krzakowski, Maciej, Milanowski, Janusz
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Netherlands 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681747/
https://ncbi.nlm.nih.gov/pubmed/26277606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12253-015-9966-z
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