The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients

In NSCLC, second-line chemotherapy using pemetrexed or docetaxel has limited efficacy and should be dedicated to selected groups of patients. Pemetrexed is an antifolate compound with the ability to inhibit enzymes (TS, DHFR and GARFT) involved in pyrimidine and purine synthesis. The objective of th...

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Vydáno v:Pathol Oncol Res
Hlavní autoři: Kucharczyk, Tomasz, Krawczyk, Paweł, Powrózek, Tomasz, Kowalski, Dariusz M., Ramlau, Rodryg, Kalinka-Warzocha, Ewa, Knetki-Wróblewska, Magdalena, Winiarczyk, Kinga, Krzakowski, Maciej, Milanowski, Janusz
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681747/
https://ncbi.nlm.nih.gov/pubmed/26277606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12253-015-9966-z
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