C609T Polymorphism of NADPH Quinone Oxidoreductase 1 Correlates Clinical Hematological Toxicities in Lung Cancer Patients Treated with Amrubicin

BACKGROUND: Amrubicin hydrochloride (AMR) is a key agent for lung cancer. NADPH quinone oxidoreductase 1 (NQO1) metabolizes the quinone structures contained in both amrubicin (AMR) and amrubicinol (AMR-OH). We hypothesized that NQO1 C609T polymorphism may affect AMR-related pharmacokinetics and clin...

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Detalhes bibliográficos
Main Authors: Nagata, Misato, Kimura, Tatsuo, Suzumura, Tomohiro, Kira, Yukimi, Nakai, Toshiyuki, Umekawa, Kanako, Tanaka, Hidenori, Matsuura, Kuniomi, Mitsuoka, Shigeki, Yoshimura, Naruo, Oka, Takako, Kudoh, Shinzoh, Hirata, Kazuto
Formato: Artigo
Idioma:Inglês
Publicado em: Libertas Academica 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576865/
https://ncbi.nlm.nih.gov/pubmed/23467445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/CMO.S10839
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