Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer

BACKGROUND: Rash, liver dysfunction, and diarrhea are known major adverse events associated with erlotinib and gefitinib. However, clinical trials with gefitinib have reported different proportions of adverse events compared to trials with erlotinib. In an in vitro study, cytochrome P450 (CYP) 2D6 w...

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Detalhes bibliográficos
Main Authors: Suzumura, Tomohiro, Kimura, Tatsuo, Kudoh, Shinzoh, Umekawa, Kanako, Nagata, Misato, Matsuura, Kuniomi, Tanaka, Hidenori, Mitsuoka, Shigeki, Yoshimura, Naruo, Kira, Yukimi, Nakai, Toshiyuki, Hirata, Kazuto
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536666/
https://ncbi.nlm.nih.gov/pubmed/23207012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-568
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