Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers

OBJECTIVE: The apolipoprotein E (APOE) ε4 allele enhances cerebral accumulation of β-amyloid (Aβ) and is a major risk factor for sporadic Alzheimer’s disease (AD). We hypothesized that HIV-associated neurocognitive disorders (HAND) would be associated with the APOE ε4 genotype and cerebral Aβ deposi...

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Hlavní autoři: Soontornniyomkij, Virawudh, Moore, David J., Gouaux, Ben, Soontornniyomkij, Benchawanna, Tatro, Erick T., Umlauf, Anya, Masliah, Eliezer, Levine, Andrew J., Singer, Elyse J., Vinters, Harry V., Gelman, Benjamin B., Morgello, Susan, Cherner, Mariana, Grant, Igor, Achim, Cristian L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576852/
https://ncbi.nlm.nih.gov/pubmed/23018443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e32835a117c
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