Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

BACKGROUND: Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited by inflammation mediates tissue damage. METHODS/PRINCIPAL FINDINGS: To monitor the demyelination and axonal injury associated wi...

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Main Authors: di Penta, Alessandra, Moreno, Beatriz, Reix, Stephanie, Fernandez-Diez, Begoña, Villanueva, Maite, Errea, Oihana, Escala, Nagore, Vandenbroeck, Koen, Comella, Joan X., Villoslada, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576396/
https://ncbi.nlm.nih.gov/pubmed/23431360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054722
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