Hemodynamic and Hormonal Changes to Dual Renin Angiotensin System Inhibition in Experimental Hypertension

We examined the antihypertensive effects of valsartan, aliskiren or both drugs combined on circulating, cardiac and renal components of the renin-angiotensin system (RAS) in congenic mRen2.Lewis hypertensive rats assigned to: vehicle (n=9), valsartan (via drinking water, 30 mg/kg/day; n=10), aliskir...

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Detalhes bibliográficos
Main Authors: Moniwa, Norihito, Varagic, Jasmina, Ahmad, Sarfaraz, VonCannon, Jessica L., Simington, Stephen W., Wang, Hao, Groban, Leanne, Brosnihan, K. Bridget, Nagata, Sayaka, Kato, Johji, Kitamura, Kazuo, Gomez, R. Ariel, Lopez, Maria L. Sequeira, Ferrario, Carlos M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576205/
https://ncbi.nlm.nih.gov/pubmed/23232645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.201889
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