Epoxyeicosatrienoic Acids (EETs) Regulate Epithelial Sodium Channel Activity by Extracellular Signal-regulated Kinase 1/2 (ERK1/2)-mediated Phosphorylation

The epithelial sodium channel (ENaC) participates in the regulation of plasma sodium and volume, and gain of function mutations in the human channel cause salt-sensitive hypertension. Roles for the arachidonic acid epoxygenase metabolites, the epoxyeicosatrienoic acids (EETs), in ENaC activity have...

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Bibliografske podrobnosti
Main Authors: Pidkovka, Nataliya, Rao, Reena, Mei, Shaojun, Gong, Yan, Harris, Raymond C., Wang, Wen-Hui, Capdevila, Jorge H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576126/
https://ncbi.nlm.nih.gov/pubmed/23283969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.407981
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