Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases

The mechanism(s) underlying neurodegeneration-associated activation of ERK1/2 remain poorly understood. We report that in cultured rat cortical neurons, whose basal ERK1/2 phosphorylation required NMDA receptors (NMDAR), the neurotoxic DNA intercalating drug cisplatin increased ERK1/2 phosphorylatio...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Gozdz, Agata, Vashishta, Aruna, Kalita, Katarzyna, Szatmari, Erzsebet, Zheng, Jing-Juan, Tamiya, Shigeo, Delamere, Nicholas A., Hetman, Michal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574929/
https://ncbi.nlm.nih.gov/pubmed/18665890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05550.x
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky