Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases

The mechanism(s) underlying neurodegeneration-associated activation of ERK1/2 remain poorly understood. We report that in cultured rat cortical neurons, whose basal ERK1/2 phosphorylation required NMDA receptors (NMDAR), the neurotoxic DNA intercalating drug cisplatin increased ERK1/2 phosphorylatio...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gozdz, Agata, Vashishta, Aruna, Kalita, Katarzyna, Szatmari, Erzsebet, Zheng, Jing-Juan, Tamiya, Shigeo, Delamere, Nicholas A., Hetman, Michal
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574929/
https://ncbi.nlm.nih.gov/pubmed/18665890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05550.x
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