Disulfide Scrambling Describes the Oligomer Formation of Superoxide Dismutase (SOD1) Proteins in the Familial Form of Amyotrophic Lateral Sclerosis

Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) are a cause of a familial form of amyotrophic lateral sclerosis. Wild-type SOD1 forms a highly conserved intra-molecular disulfide bond, whereas pathological SOD1 proteins are cross-linked via intermolecular disulfide bonds and form insoluble o...

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Detaylı Bibliyografya
Asıl Yazarlar: Toichi, Keisuke, Yamanaka, Koji, Furukawa, Yoshiaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576100/
https://ncbi.nlm.nih.gov/pubmed/23264618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414235
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