NADPH:Quinone Oxidoreductase 1 Regulates Host Susceptibility to Ozone via Isoprostane Generation

NADPH:quinone oxidoreductase 1 (NQO1) is recognized as a major susceptibility gene for ozone-induced pulmonary toxicity. In the absence of NQO1 as can occur by genetic mutation, the human airway is protected from harmful effects of ozone. We recently reported that NQO1-null mice are protected from a...

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Detalles Bibliográficos
Autores principales: Kummarapurugu, Apparao B., Fischer, Bernard M., Zheng, Shuo, Milne, Ginger L., Ghio, Andrew J., Potts-Kant, Erin N., Foster, W. Michael, Soderblom, Erik J., Dubois, Laura G., Moseley, M. Arthur, Thompson, J. Will, Voynow, Judith A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576073/
https://ncbi.nlm.nih.gov/pubmed/23275341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438440
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