NAD(P)H Quinone Oxidoreductase 1 Is Essential for Ozone-Induced Oxidative Stress in Mice and Humans

One host susceptibility factor for ozone identified in epidemiologic studies is NAD(P)H quinone oxidoreductase 1 (NQO1). We hypothesized that after ozone exposure, NQO1 is required to increase 8-isoprostane (also known as F(2)-isoprostane) production, a recognized marker of ozone-induced oxidative s...

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Главные авторы: Voynow, Judith A., Fischer, Bernard M., Zheng, Shuo, Potts, Erin N., Grover, Amy R., Jaiswal, Anil K., Ghio, Andrew J., Foster, W. Michael
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701957/
https://ncbi.nlm.nih.gov/pubmed/19059883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0381OC
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