Old Drug, New Target: ELLIPTICINES SELECTIVELY INHIBIT RNA POLYMERASE I TRANSCRIPTION

Transcription by RNA polymerase I (Pol-I) is the main driving force behind ribosome biogenesis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-I transcription and the concurrent increase in ribosome biogenesis has been linke...

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Detalhes bibliográficos
Main Authors: Andrews, William J., Panova, Tatiana, Normand, Christophe, Gadal, Olivier, Tikhonova, Irina G., Panov, Konstantin I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576063/
https://ncbi.nlm.nih.gov/pubmed/23293027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411611
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