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Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs. Here we uncover a role for topoisomerase IIα...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615473/ https://ncbi.nlm.nih.gov/pubmed/23511463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2599 |
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