Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation

Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs. Here we uncover a role for topoisomerase IIα...

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Autores principales: Ray, Swagat, Panova, Tatiana, Miller, Gail, Volkov, Arsen, Porter, Andrew C. G., Russell, Jackie, Panov, Konstantin I., Zomerdijk, Joost C. B. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615473/
https://ncbi.nlm.nih.gov/pubmed/23511463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2599
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