Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6

INTRODUCTION: The c-Jun N-terminal kinases (JNKs) are involved in signal transduction of inflammatory bowel diseases. The aim of this study was to examine the function of JNKs by using a low-dose dextran sulfate sodium (DSS) model in JNK1 knockout mice (Mapk8−/−), JNK2 knockout mice (Mapk9−/−), and...

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Main Authors: Kersting, Sabine, Reinecke, Kirstin, Hilgert, Christoph, Janot, Monika S, Haarmann, Elisabeth, Albrecht, Martin, Müller, Annette M, Herdegen, Thomas, Mittelkötter, Ulrich, Uhl, Waldemar, Chromik, Ansgar M
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576002/
https://ncbi.nlm.nih.gov/pubmed/23426157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S36415
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