Simultaneous oral therapeutic and intravenous (14)C‐microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin

AIM: To determine the absolute oral bioavailability (F(p.o.)) of saxagliptin and dapagliflozin using simultaneous intravenous (14)C‐microdose/therapeutic oral dosing (i.v.micro + oraltherap). METHODS: The F(p.o.) values of saxagliptin and dapagliflozin were determined in healthy subjects (n = 7 and...

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Detalhes bibliográficos
Main Authors: Boulton, David W., Kasichayanula, Sreeneeranj, Keung, Chi Fung (Anther), Arnold, Mark E., Christopher, Lisa J., Xu, Xiaohui (Sophia), LaCreta, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575942/
https://ncbi.nlm.nih.gov/pubmed/22823746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04391.x
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