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Characterizing antiprion compounds based on their binding properties to prion proteins: Implications as medical chaperones

A variety of antiprion compounds have been reported that are effective in ex vivo and in vivo treatment experiments. However, the molecular mechanisms for most of these compounds remain unknown. Here we classified antiprion mechanisms into four categories: I, specific conformational stabilization; I...

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Bibliographic Details
Main Authors: Kamatari, Yuji O, Hayano, Yosuke, Yamaguchi, Kei-ichi, Hosokawa-Muto, Junji, Kuwata, Kazuo
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575857/
https://ncbi.nlm.nih.gov/pubmed/23081827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2180
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