Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil

Archaeal family-B DNA polymerases bind tightly to deaminated bases and stall replication on encountering uracil in template strands, four bases ahead of the primer-template junction. Should the polymerase progress further towards the uracil, for example, to position uracil only two bases in front of...

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Bibliographische Detailangaben
Hauptverfasser: Richardson, Tomas T., Wu, Xiaohua, Keith, Brian J., Heslop, Pauline, Jones, Anita C., Connolly, Bernard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575838/
https://ncbi.nlm.nih.gov/pubmed/23303790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1364
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