Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome

The mitochondrial genome exists in numerous structural conformations, complicating the study of mitochondrial DNA (mtDNA) metabolism. Here, we describe the development of 2D intact mtDNA agarose gel electrophoresis (2D-IMAGE) for the separation and detection of approximately two-dozen distinct topoi...

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Bibliographische Detailangaben
Hauptverfasser: Kolesar, Jill E., Wang, Catherine Y., Taguchi, Yumiko V., Chou, Shih-Hsuan, Kaufman, Brett A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575812/
https://ncbi.nlm.nih.gov/pubmed/23275548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1324
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