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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the fraction of cancer cells harboring each somatic mutation. We identified driver...
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575604/ https://ncbi.nlm.nih.gov/pubmed/23415222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.01.019 |
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