Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease with a strong genetic component. African-Americans (AA) are at increased risk of SLE, but the genetic basis of this risk is largely unknown. To identify causal variants in SLE loci in AA, we performed admixture mapping followed...

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Main Authors: Molineros, Julio E., Maiti, Amit K., Sun, Celi, Looger, Loren L., Han, Shizhong, Kim-Howard, Xana, Glenn, Stuart, Adler, Adam, Kelly, Jennifer A., Niewold, Timothy B., Gilkeson, Gary S., Brown, Elizabeth E., Alarcón, Graciela S., Edberg, Jeffrey C., Petri, Michelle, Ramsey-Goldman, Rosalind, Reveille, John D., Vilá, Luis M., Freedman, Barry I., Tsao, Betty P., Criswell, Lindsey A., Jacob, Chaim O., Moore, Jason H., Vyse, Timothy J., Langefeld, Carl L., Guthridge, Joel M., Gaffney, Patrick M., Moser, Kathy L., Scofield, R. Hal, Alarcón-Riquelme, Marta E., Williams, Scott M., Merrill, Joan T., James, Judith A., Kaufman, Kenneth M., Kimberly, Robert P., Harley, John B., Nath, Swapan K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575474/
https://ncbi.nlm.nih.gov/pubmed/23441136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003222
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