REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1

REV1 is a Y-family polymerase specialized for replicating across DNA lesions at the stalled replication folk. Due to the high error rate of REV1-dependent translesion DNA synthesis (TLS), tight regulation of REV1 activity is essential. Here, we show that human REV1 undergoes proteosomal degradation...

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Hlavní autoři: Chun, Abel Chiu-Shun, Kok, Kin-Hang, Jin, Dong-Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
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Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575465/
https://ncbi.nlm.nih.gov/pubmed/23287467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23214
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