HLA-B35 and dsRNA Induce Endothelin-1 via Activation of ATF4 in Human Microvascular Endothelial Cells

Endothelin 1 (ET-1) is a key regulator of vascular homeostasis. We have recently reported that the presence of Human antigen class I, HLA-B35, contributes to human dermal microvascular endothelial cell (HDMEC) dysfunction by upregulating ET-1 and proinflammatory genes. Likewise, a Toll-like receptor...

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Hlavní autoři: Lenna, Stefania, Chrobak, Izabela, Farina, G. Alessandra, Rodriguez-Pascual, Fernando, Lamas, Santiago, Lafyatis, Robert, Scorza, Raffaella, Trojanowska, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575387/
https://ncbi.nlm.nih.gov/pubmed/23441162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056123
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