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Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives

N,S-diprotected L-thiothreonine and L-allo-thiothreonine derivatives were synthesized using a novel chemical strategy, and used for esterification of the dinucleotide pdCpA. The aminoacylated dinucleotides were then employed for the preparation of activated suppressor tRNA(CUA) transcripts. Thiothre...

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Autori principali: Chen, Shengxi, Fahmi, Nour Eddine, Nangreave, Ryan C., Mehellou, Youcef, Hecht, Sidney M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575115/
https://ncbi.nlm.nih.gov/pubmed/22405920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.024
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