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Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes

TRIM5 is a host antiviral gene with an evolutionary history of genetic conflict with retroviruses. The TRIMCyp gene encodes a protein fusion of TRIM5 effector domains with the capsid-binding ability of a retrotransposed CyclophilinA (CypA), resulting in novel antiviral specificity against lentivirus...

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Hlavní autoři: Malfavon-Borja, Ray, Wu, Lily I., Emerman, Michael, Malik, Harmit Singh
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574956/
https://ncbi.nlm.nih.gov/pubmed/23319649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216542110
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