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Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
Rhomboid proteases are evolutionary conserved intramembrane serine proteases. Because of their emerging role in many important biological pathways, rhomboids are potential drug targets. Unfortunately, few chemical tools are available for their study. Here, we describe a mass spectrometry-based assay...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574917/ https://ncbi.nlm.nih.gov/pubmed/23359682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215076110 |
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