Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

Sphingosine-1-phosphate (S1P), a ligand for 5 specific receptors, is a potent lipid mediator that plays important roles in lymphocyte trafficking and immune responses. S1P is produced inside cells and therefore must be secreted to exert its effects through these receptors. Spinster 2 (Spns2) is one...

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Main Authors: Nagahashi, Masayuki, Kim, Eugene Y., Yamada, Akimitsu, Ramachandran, Subramaniam, Allegood, Jeremy C., Hait, Nitai C., Maceyka, Michael, Milstien, Sheldon, Takabe, Kazuaki, Spiegel, Sarah
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2013
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574288/
https://ncbi.nlm.nih.gov/pubmed/23180825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-219618
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