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Human DNA polymerase β, but not λ, can bypass a 2-deoxyribonolactone lesion together with proliferating cell nuclear antigen
The C1′-oxidized lesion 2-deoxyribonolactone (L) is induced by free radical attack of DNA. This lesion is mutagenic, inhibits base excision repair, and can lead to strand scission. In double stranded DNA L is repaired by long-patch base excision repair, but it induces replication fork arrest in a si...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574196/ https://ncbi.nlm.nih.gov/pubmed/23101935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300542k |
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