Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences

‘Classical’ non-homologous end joining (NHEJ), dependent on the Ku70/80 and the DNA ligase IV/XRCC4 complexes, is essential for the repair of DNA double-strand breaks. Eukaryotic cells possess also an alternative microhomology-mediated end-joining (MMEJ) mechanism, which is independent from Ku and D...

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Hlavní autoři: Crespan, Emmanuele, Czabany, Tibor, Maga, Giovanni, Hübscher, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384310/
https://ncbi.nlm.nih.gov/pubmed/22373917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks186
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