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The TRPM6/EGF Pathway Is Downregulated in a Rat Model of Cisplatin Nephrotoxicity
Cisplatin-induced hypomagnesemia is described in humans and rats, but the underlying mechanisms are still unclear. Recent studies have shown that epidermal growth factor (EGF) stimulates Mg(2+) re-absorption in the distal convoluted tubule via the Mg(2+) channel TRPM6. This study investigates the ro...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574071/ https://ncbi.nlm.nih.gov/pubmed/23457647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057016 |
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