p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists

ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >70% of the transcriptomic response to endotheli...

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Autores principales: Amirak, Emre, Fuller, Stephen J., Sugden, Peter H., Clerk, Angela
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573779/
https://ncbi.nlm.nih.gov/pubmed/23215897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121371
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