Inhibiting CXCL12 Blocks Fibrocyte Migration and Differentiation and Attenuates Bronchiolitis Obliterans in a Murine Heterotopic Tracheal Transplant Model

OBJECTIVES: Fibrocytes are integral in the development of fibroproliferative disease post lung transplantation. Undifferentiated fibrocytes (CD45+Col1+CXCR4+) preferentially traffic via the CXCR4/CXCL12 axis and differentiate into smooth muscle actin producing (CD45+CXCR4+αSMA+) cells. We postulated...

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Main Authors: Harris, David A., Zhao, Yunge, LaPar, Damien J., Emaminia, Abbas, Steidle, John F., Stoler, Mark, Linden, Joel, Kron, Irving L., Lau, Christine L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573249/
https://ncbi.nlm.nih.gov/pubmed/22626514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2012.03.079
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