Rapamycin Blocks Fibrocyte Migration and Attenuates Bronchiolitis Obliterans in a Murine Model

BACKGROUND: Fibrocytes are integral in the development of fibroproliferative disease. The CXCL12/CXCR4 chemokine axis has been shown to play a central role in fibrocyte migration and the development of bronchiolitis obliterans post lung transplantation. Inhibition of the mTOR (mammalian target of ra...

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Publicat a:Ann Thorac Surg
Autors principals: Gillen, Jacob R., Zhao, Yunge, Harris, David A., LaPar, Damien J., Stone, Matthew L., Fernandez, Lucas G., Kron, Irving L., Lau, Christine L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218735/
https://ncbi.nlm.nih.gov/pubmed/23561805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2013.02.021
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