EVI1 Inhibits Apoptosis Induced by Antileukemic Drugs via Upregulation of CDKN1A/p21/WAF in Human Myeloid Cells

Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...

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Autors principals: Rommer, Anna, Steinmetz, Birgit, Herbst, Friederike, Hackl, Hubert, Heffeter, Petra, Heilos, Daniela, Filipits, Martin, Steinleitner, Katarina, Hemmati, Shayda, Herbacek, Irene, Schwarzinger, Ilse, Hartl, Katharina, Rondou, Pieter, Glimm, Hanno, Karakaya, Kadin, Krämer, Alwin, Berger, Walter, Wieser, Rotraud
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572987/
https://ncbi.nlm.nih.gov/pubmed/23457546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056308
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