EVI1 Inhibits Apoptosis Induced by Antileukemic Drugs via Upregulation of CDKN1A/p21/WAF in Human Myeloid Cells

Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...

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Détails bibliographiques
Auteurs principaux: Rommer, Anna, Steinmetz, Birgit, Herbst, Friederike, Hackl, Hubert, Heffeter, Petra, Heilos, Daniela, Filipits, Martin, Steinleitner, Katarina, Hemmati, Shayda, Herbacek, Irene, Schwarzinger, Ilse, Hartl, Katharina, Rondou, Pieter, Glimm, Hanno, Karakaya, Kadin, Krämer, Alwin, Berger, Walter, Wieser, Rotraud
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572987/
https://ncbi.nlm.nih.gov/pubmed/23457546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056308
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