EVI1 Inhibits Apoptosis Induced by Antileukemic Drugs via Upregulation of CDKN1A/p21/WAF in Human Myeloid Cells

Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...

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Hauptverfasser: Rommer, Anna, Steinmetz, Birgit, Herbst, Friederike, Hackl, Hubert, Heffeter, Petra, Heilos, Daniela, Filipits, Martin, Steinleitner, Katarina, Hemmati, Shayda, Herbacek, Irene, Schwarzinger, Ilse, Hartl, Katharina, Rondou, Pieter, Glimm, Hanno, Karakaya, Kadin, Krämer, Alwin, Berger, Walter, Wieser, Rotraud
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572987/
https://ncbi.nlm.nih.gov/pubmed/23457546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056308
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