Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

Traumatic brain injury (TBI) causes chronic microglial activation that contributes to subsequent neurodegeneration, with clinical outcomes declining as a function of aging. Microglia/macrophages (MG/MΦ) have multiple phenotypes, including a classically activated, pro-inflammatory (M1) state that may...

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Bibliografiske detaljer
Main Authors: Kumar, Alok, Stoica, Bogdan A., Sabirzhanov, Boris, Burns, Mark P., Faden, Alan I., Loane, David J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572914/
https://ncbi.nlm.nih.gov/pubmed/23273602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.11.013
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