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Deregulated Nras Expression in Knock-In Animals Harboring a Gammaretroviral Long Terminal Repeat at the Nras/Csde1 Locus

To investigate mechanisms and phenotypic effects of insertional mutagenesis by gammaretroviruses, we have developed mouse lines containing a single Akv 1-99 long terminal repeat (LTR) and a floxed PGK/Tn5 neomycin cassette at the Nras proto-oncogene at positions previously identified as viral integr...

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Detalhes bibliográficos
Main Authors: Ballarín-González, Borja, Lassen, Louise Berkhoudt, Jessen, Randi, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Pedersen, Finn Skou
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572152/
https://ncbi.nlm.nih.gov/pubmed/23418499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056029
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