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Nras Overexpression Results in Granulocytosis, T-Cell Expansion and Early Lethality in Mice

NRAS is a proto-oncogene involved in numerous myeloid malignancies. Here, we report on a mouse line bearing a single retroviral long terminal repeat inserted into Nras. This genetic modification resulted in an increased level of wild type Nras mRNA giving the possibility of studying the function and...

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書誌詳細
主要な著者: Lassen, Louise Berkhoudt, Ballarín-González, Borja, Schmitz, Alexander, Füchtbauer, Annette, Pedersen, Finn Skou, Füchtbauer, Ernst-Martin
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410918/
https://ncbi.nlm.nih.gov/pubmed/22876308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042216
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