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Nras Overexpression Results in Granulocytosis, T-Cell Expansion and Early Lethality in Mice
NRAS is a proto-oncogene involved in numerous myeloid malignancies. Here, we report on a mouse line bearing a single retroviral long terminal repeat inserted into Nras. This genetic modification resulted in an increased level of wild type Nras mRNA giving the possibility of studying the function and...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410918/ https://ncbi.nlm.nih.gov/pubmed/22876308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042216 |
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