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Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells

Mucin 1 (MUC1) is a heterodimeric glycoprotein that is aberrantly overexpressed in most human breast cancers. The oncogenic MUC1-C subunit promotes survival and blocks the apoptotic response to genotoxic anticancer agents. In the present studies, human MCF-7 and ZR-75-1 breast cancer cells were trea...

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Sonraí Bibleagrafaíochta
Main Authors: Uchida, Yasumitsu, Raina, Deepak, Kharbanda, Surender, Kufe, Donald
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571994/
https://ncbi.nlm.nih.gov/pubmed/23114713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.22634
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