M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

BACKGROUND: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. FINDINGS: To address this problem, here, we report that pretreatment of HIV-infected peri...

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Autores principales: Selhorst, Philippe, Grupping, Katrijn, Tong, Tommy, Crooks, Ema T, Martin, Loïc, Vanham, Guido, Binley, James M, Ariën, Kevin K
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571899/
https://ncbi.nlm.nih.gov/pubmed/23375046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-12
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