Molecular Mechanisms Underlying Oseltamivir Resistance Mediated by an I117V Substitution in the Neuraminidase of Subtype H5N1 Avian Influenza A Viruses

Background. The neuraminidase (NA) inhibitor oseltamivir is widely used to treat patients infected with influenza viruses. An Ile-to-Val change at position 117 in influenza A virus subtype H5N1 NA (NA-I117V) confers a reduction in susceptibility to oseltamivir carboxylate. However, the in vivo relev...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Takano, Ryo, Kiso, Maki, Igarashi, Manabu, Le, Quynh Mai, Sekijima, Masakazu, Ito, Kimihito, Takada, Ayato, Kawaoka, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571237/
https://ncbi.nlm.nih.gov/pubmed/23053629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis633
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