The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting RGD ligands with a build-in handle

The αvβ3 integrin, expressed on the surface of various normal and cancer cells, is involved in numerous physiological processes such as angiogenesis, apoptosis, and bone resorption. Because this integrin plays a key role in angiogenesis and metastasis of human tumors, αvβ3 integrin ligands are of gr...

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Hauptverfasser: Xiao, Wenwu, Wang, Yan, Lau, Edmond Y., Luo, Juntao, Yao, Nianhuan, Shi, Changying, Meza, Leah, Tseng, Harry, Maeda, Yoshiko, Kumaresan, Pappanaicken, Liu, Ruiwu, Lightstone, Felice C., Takada, Yoshikazu, Lam, Kit S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571112/
https://ncbi.nlm.nih.gov/pubmed/20858725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0308
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