Discovery of Targeting Ligands for Breast Cancer Cells Using the One-Bead One-Compound Combinatorial Method

Four “One-bead one-compound” (OBOC) combinatorial libraries were designed, synthesized, and screened against MDA-MB-231 breast cancer cells. A novel cyclic peptide 1 (LXY1) with high binding specificity to α3 integrin, was identified. Molecular interactions between α3 integrin and 1 were characteriz...

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Huvudupphovsmän: Yao, Nianhuan, Xiao, Wenwu, Wang, Xiaobing, Marik, Jan, Park, See Hyoung, Lam, Kit S
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836207/
https://ncbi.nlm.nih.gov/pubmed/19055415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801062d
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