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Discovery of Targeting Ligands for Breast Cancer Cells Using the One-Bead One-Compound Combinatorial Method
Four “One-bead one-compound” (OBOC) combinatorial libraries were designed, synthesized, and screened against MDA-MB-231 breast cancer cells. A novel cyclic peptide 1 (LXY1) with high binding specificity to α3 integrin, was identified. Molecular interactions between α3 integrin and 1 were characteriz...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2836207/ https://ncbi.nlm.nih.gov/pubmed/19055415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801062d |
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