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Bioreducible polymers as a determining factor for polyplex decomplexation rate and transfection

Polyplex formation (complexation) and gene release from the polyplexes (decomplexation) are major events in polymeric gene delivery, however the effect of the decomplexation rate on transfection has been rarely investigated. This study employed mixed polymers of poly(L-lysine) (PLL: MW ~7.4 kDa) and...

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Hlavní autoři: Hwang, Hee Sook, Kang, Han Chang, Bae, You Han
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570707/
https://ncbi.nlm.nih.gov/pubmed/23259985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm301794d
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