Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen

We have previously demonstrated that immunization with inactivated Francisella tularensis, a Category A intracellular mucosal pathogen, combined with IgG2a anti-F. tularensis monoclonal antibody, enhances protection against subsequent F. tularensis challenge. To understand the mechanism(s) involved,...

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Detalhes bibliográficos
Main Authors: Iglesias, Bibiana V., Bitsaktsis, Constantine, Pham, Giang, Drake, James R., Hazlett, Karsten R.O., Porter, Kristen, Gosselin, Edmund J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570671/
https://ncbi.nlm.nih.gov/pubmed/23247654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2012.66
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