Structure of phosphorylated SF1 bound to U2AF(65) in an essential splicing factor complex

The essential splicing factors U2AF(65) and SF1 cooperatively bind consensus sequences at the 3′ end of introns. Phosphorylation of SF1 on a highly conserved ‘SPSP’ motif enhances its interaction with U2AF(65) and the pre-mRNA. Here we reveal that phosphorylation-induces essential conformational cha...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Wenhua, Maucuer, Alexandre, Gupta, Ankit, Manceau, Valérie, Thickman, Karen R., Bauer, William J., Kennedy, Scott D., Wedekind, Joseph E., Green, Michael R., Kielkopf, Clara L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570649/
https://ncbi.nlm.nih.gov/pubmed/23273425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.10.020
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