Excessive Fibrin Deposition in Nasal Polyps Caused by Fibrinolytic Impairment through Reduction of Tissue Plasminogen Activator Expression

Rationale: Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. Objectives: We hypothesized that formation of a fibrin mesh...

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Hlavní autoři: Takabayashi, Tetsuji, Kato, Atsushi, Peters, Anju T., Hulse, Kathryn E., Suh, Lydia A., Carter, Roderick, Norton, James, Grammer, Leslie C., Cho, Seong H., Tan, Bruce K., Chandra, Rakesh K., Conley, David B., Kern, Robert C., Fujieda, Shigeharu, Schleimer, Robert P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3570641/
https://ncbi.nlm.nih.gov/pubmed/23155140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201207-1292OC
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